Proliferative activity of cyst epithelium in human renal cystic diseases.

T Nadasdy, Z Laszik, G Lajoie, KE Blick… - Journal of the …, 1995 - journals.lww.com
Increased proliferative activity of the renal tubular epithelium is thought to be a prerequisite
for renal cyst formation by many investigators. However, in humans, the exact in vivo
proliferation rate of epithelial cells lining these cysts is not known. In this study, which used
immunohistochemical methods with an antibody to proliferating cell nuclear antigen (PCNA),
the proliferation index (PI)(percentage of PCNA positive cell nuclei among epithelial cells
lining the renal cysts) was determined in 10 cases of autosomal dominant polycystic kidney …