Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease
Y Tao, J Kim, RW Schrier… - Journal of the American …, 2005 - journals.lww.com
Increased tubular epithelial cell proliferation is a prerequisite for cyst formation and
expansion in polycystic kidney disease (PKD). Rapamycin is a potent antiproliferative agent.
The aim of the present study was to determine the effect of rapamycin on tubular cell
proliferation, cyst formation, and renal failure in the Han: SPRD rat model of PKD.
Heterozygous (Cy/+) and littermate control (+/+) male rats were weaned at 3 wk of age and
then treated with rapamycin 0.2 mg/kg per d intraperitoneally or vehicle (ethanol) for 5 wk …
expansion in polycystic kidney disease (PKD). Rapamycin is a potent antiproliferative agent.
The aim of the present study was to determine the effect of rapamycin on tubular cell
proliferation, cyst formation, and renal failure in the Han: SPRD rat model of PKD.
Heterozygous (Cy/+) and littermate control (+/+) male rats were weaned at 3 wk of age and
then treated with rapamycin 0.2 mg/kg per d intraperitoneally or vehicle (ethanol) for 5 wk …
