Despite identification of the genes responsible for autosomal dominant polycystic kidney
disease (PKD) and autosomal recessive PKD (ARPKD), the precise functions of their
cystoprotein products remain unknown. Recent data suggested that multimeric cystoprotein
complexes initiate aberrant signaling cascades in PKD, and common components of these
signaling pathways may be therapeutic targets. This study identified c-Src (pp60 c-Src) as
one such common signaling intermediate and sought to determine whether Src activity plays …