Identification of putative gene based markers of renal toxicity.
RP Amin, AE Vickers, F Sistare… - Environmental …, 2004 - ehp.niehs.nih.gov
This study, designed and conducted as part of the International Life Sciences Institute
working group on the Application of Genomics and Proteomics, examined the changes in
the expression profile of genes associated with the administration of three different
nephrotoxicants--cisplatin, gentamicin, and puromycin--to assess the usefulness of
microarrays in the understanding of mechanism (s) of nephrotoxicity. Male Sprague-Dawley
rats were treated with daily doses of puromycin (5-20 mg/kg/day for 21 days), gentamicin (2 …
working group on the Application of Genomics and Proteomics, examined the changes in
the expression profile of genes associated with the administration of three different
nephrotoxicants--cisplatin, gentamicin, and puromycin--to assess the usefulness of
microarrays in the understanding of mechanism (s) of nephrotoxicity. Male Sprague-Dawley
rats were treated with daily doses of puromycin (5-20 mg/kg/day for 21 days), gentamicin (2 …