Sirt1–Claudin-1 crosstalk regulates renal function
D Nihalani, K Susztak - Nature Medicine, 2013 - nature.com
D Nihalani, K Susztak
Nature Medicine, 2013•nature.comUnderstanding the molecular mechanisms that govern diabetes-induced loss of kidney
function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in
the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key
regulator of albuminuria and glomerular function (pages 1496–1504).
function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in
the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key
regulator of albuminuria and glomerular function (pages 1496–1504).
Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and glomerular function (pages 1496–1504).
nature.com