[HTML][HTML] Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes
C Bertuccio, D Veron, PK Aggarwal, L Holzman… - Journal of Biological …, 2011 - ASBMB
The transmembrane protein nephrin is an essential component of slit diaphragms, the
specialized cell junctions that link podocyte foot processes. Podocytes are epithelial cells
that surround the glomerular capillaries in the kidney and are necessary for the organ-
filtering function. Nephrin signaling complex transduces extracellular cues to the podocyte
cytoskeleton and regulates podocyte shape and function. Vascular endothelial growth factor
A (VEGF-A) is a required growth factor produced and secreted by podocytes. Accumulating …
specialized cell junctions that link podocyte foot processes. Podocytes are epithelial cells
that surround the glomerular capillaries in the kidney and are necessary for the organ-
filtering function. Nephrin signaling complex transduces extracellular cues to the podocyte
cytoskeleton and regulates podocyte shape and function. Vascular endothelial growth factor
A (VEGF-A) is a required growth factor produced and secreted by podocytes. Accumulating …