Leukemia inhibitory factor involvement in human ulcerative colitis and its potential role in malignant course.

R Guimbaud, V Abitbol, V Bertrand, G Quartier… - European cytokine …, 1999 - jle.com
R Guimbaud, V Abitbol, V Bertrand, G Quartier, L Chauvelot-Moachon, JP Giroud…
European cytokine network, 1999jle.com
LIF, a member of the hematopoietic family of growth factors, is a pleitropic cytokine initially
identified by its growth-promoting activity on the murine IL-3-dependent DA-1 cell line [1].
Since, several other activities have been ascribed to LIF, mainly: proinflammatory actions,
tumorogenesis and embryonic development. LIF has been detected in normal as well as in
tumor cells. In normal adult mouse many tissues express transcripts of LIF at very low levels,
in particular the skin and intestinale tissues [2] and LIF is present in most human tissues [3] …
LIF, a member of the hematopoietic family of growth factors, is a pleitropic cytokine initially identified by its growth-promoting activity on the murine IL-3-dependent DA-1 cell line [1]. Since, several other activities have been ascribed to LIF, mainly: proinflammatory actions, tumorogenesis and embryonic development. LIF has been detected in normal as well as in tumor cells. In normal adult mouse many tissues express transcripts of LIF at very low levels, in particular the skin and intestinale tissues [2] and LIF is present in most human tissues [3]. Moreover, receptors for LIF have been detected on the cell surface of certain human solid tumor cell lines such as melanoma, neuroblastoma, and colonic and placental tissues although their functional significance remains unknown [4].
Together with IL-6, IL-1 and TNF-alpha, LIF is produced by many cells types known to be involved in inflammation, namely activated lymphocytes and monocytes, T cells, polymorphonuclears and fibroblasts [5, 6]. LIF shares with the main inflammatory cytokines (IL-6, IL-1 and TNF-alpha) many properties, thus behaving like a proinflammatory cytokine. Different cytokines may induce the same response. The sharing of some common biologic activities by these cytokines may be explained by the fact that they utilize gp130 as a signal transducer [7, 8]. As IL-6, LIF can also stimulate the acute-phase response. The induction of LIF by tissue damage suggests that LIF could be important for the recruitment of inflammatory cells to the site of injury and/or to promote tissue repair [9]. LIF has been detected in the serum of patients with inflammatory diseases such as sepsis [10] or giant cell arteritis [11] and in the synovial fluid and synoviocytes of rheumatoid arthritis patients [12-13]. Despite the presence of LIF in various body fluids [14] its role in human diseases remains still poorly defined.
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