[HTML][HTML] Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes
H Suzuki, M Raska, K Yamada, Z Moldoveanu… - Journal of Biological …, 2014 - ASBMB
IgA nephropathy (IgAN), the most common primary glomerulonephritis, is characterized by
renal immunodeposits containing IgA1 with galactose-deficient O-glycans (Gd-IgA1). These
immunodeposits originate from circulating immune complexes consisting of anti-glycan
antibodies bound to Gd-IgA1. As clinical disease onset and activity of IgAN often coincide
with mucosal infections and dysregulation of cytokines, we hypothesized that cytokines may
affect IgA1 O-glycosylation. We used IgA1-secreting cells derived from the circulation of …
renal immunodeposits containing IgA1 with galactose-deficient O-glycans (Gd-IgA1). These
immunodeposits originate from circulating immune complexes consisting of anti-glycan
antibodies bound to Gd-IgA1. As clinical disease onset and activity of IgAN often coincide
with mucosal infections and dysregulation of cytokines, we hypothesized that cytokines may
affect IgA1 O-glycosylation. We used IgA1-secreting cells derived from the circulation of …