O-glycosylation of serum IgD in IgA nephropathy
AC Smith, JF de Wolff, K Molyneux… - Journal of the …, 2006 - journals.lww.com
Abstract In IgA nephropathy (IgAN), serum IgA1 with abnormal O-glycosylation preferentially
deposits in the glomerular mesangium. The control of O-glycosylation is poorly understood.
Among Ig isotypes, only IgD, produced early in B cell development, and IgA1, produced by
mature B cells, are O-glycosylated. For investigation of the stage of B cell maturation at
which the defect seen in IgAN arises, the O-glycosylation of serum IgA1 and IgD was studied
in IgAN and controls. Serum was obtained from 20 patients with IgAN and 20 control …
deposits in the glomerular mesangium. The control of O-glycosylation is poorly understood.
Among Ig isotypes, only IgD, produced early in B cell development, and IgA1, produced by
mature B cells, are O-glycosylated. For investigation of the stage of B cell maturation at
which the defect seen in IgAN arises, the O-glycosylation of serum IgA1 and IgD was studied
in IgAN and controls. Serum was obtained from 20 patients with IgAN and 20 control …