Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy
J Lv, W Hou, X Zhou, G Liu, F Zhou… - Journal of the …, 2013 - journals.lww.com
Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-
DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European
population, but it is unknown whether a similar association exists in the Chinese population
and whether high-risk alleles promote the development of anti-PLA2R antibodies. Here, we
genotyped 2132 Chinese individuals, including 1112 patients with IMN and 1020 healthy
controls, for three single nucleotide polymorphisms (SNPs) within PLA2R1 and three SNPs …
DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European
population, but it is unknown whether a similar association exists in the Chinese population
and whether high-risk alleles promote the development of anti-PLA2R antibodies. Here, we
genotyped 2132 Chinese individuals, including 1112 patients with IMN and 1020 healthy
controls, for three single nucleotide polymorphisms (SNPs) within PLA2R1 and three SNPs …