Recurrent membranous nephropathy in an allograft caused by IgG3κ targeting the PLA2 receptor
H Debiec, M Hanoy, A Francois, D Guerrot… - Journal of the …, 2012 - journals.lww.com
Up to 80% of patients with idiopathic membranous nephropathy have non–complement-
fixing IgG4 autoantibodies to the phospholipase A2 receptor (PLA2R). Membranous
nephropathy recurs in approximately 40% of patients after kidney transplantation, but the
mechanism is unknown. Here, we describe a patient with recurrent membranous
nephropathy 13 days after kidney transplantation whose graft biopsy specimen showed
granular staining for C3, C5b-9, C1q, and IgG3κ; electron microscopy revealed subepithelial …
fixing IgG4 autoantibodies to the phospholipase A2 receptor (PLA2R). Membranous
nephropathy recurs in approximately 40% of patients after kidney transplantation, but the
mechanism is unknown. Here, we describe a patient with recurrent membranous
nephropathy 13 days after kidney transplantation whose graft biopsy specimen showed
granular staining for C3, C5b-9, C1q, and IgG3κ; electron microscopy revealed subepithelial …