Decades of experiments in small animalshad tipped the balance of opinion away from
antibodies as a cause of transplant rejection. However, clinical experience, especially with
sensitized patients, has convinced basic immunologists of the need to develop models to
investigate mechanisms underlying antibody‐mediated rejection (AMR). This resurgent
interest has resulted in several new rodent models to investigate antibody‐mediated
mechanisms of heart and renal allograft injury, but satisfactory models of chronic AMR …