MicroRNA-21* regulates the prosurvival effect of GM-CSF on human eosinophils

CK Wong, KM Lau, IHS Chan, S Hu, YYO Lam… - Immunobiology, 2013 - Elsevier
Eosinophils are the principal effector cells of allergic inflammation, and hematopoietic
cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) is the primary
cytokine that activates and prolongs the survival of eosinophils in local inflammatory sites by
mediating anti-apoptotic activity in allergic inflammation. To investigate the
immunopathological role of microRNA (miRNA) in allergic inflammation, we elucidated the
regulatory mechanisms of miRNA on the GM-CSF-mediated in vitro survival in eosinophils …