What causes a broken heart—molecular insights into heart failure

SP Barry, PA Townsend - International review of cell and molecular biology, 2010 - Elsevier
Our understanding of the molecular processes which regulate cardiac function has grown
immeasurably in recent years. Even with the advent of β-blockers, angiotensin inhibitors and
calcium modulating agents, heart failure (HF) still remains a seriously debilitating and life-
threatening condition. Here, we review the molecular changes which occur in the heart in
response to increased load and the pathways which control cardiac hypertrophy, calcium
homeostasis, and immune activation during HF. These can occur as a result of genetic …