[HTML][HTML] The human respiratory syncytial virus nonstructural protein 1 regulates type I and type II interferon pathways
Respiratory syncytial viruses encode a nonstructural protein (NS1) that interferes with type I
and III interferon and other antiviral responses. Proteomic studies were conducted on human
A549 type II alveolar epithelial cells and type I interferon-deficient Vero cells (African green
monkey kidney cells) infected with wild-type and NS1-deficient clones of human respiratory
syncytial virus to identify other potential pathway and molecular targets of NS1 interference.
These analyses included two-dimensional differential gel electrophoresis and quantitative …
and III interferon and other antiviral responses. Proteomic studies were conducted on human
A549 type II alveolar epithelial cells and type I interferon-deficient Vero cells (African green
monkey kidney cells) infected with wild-type and NS1-deficient clones of human respiratory
syncytial virus to identify other potential pathway and molecular targets of NS1 interference.
These analyses included two-dimensional differential gel electrophoresis and quantitative …