Balancing calcium signals through TRPC5 and TRPC6 in podocytes
A Greka, P Mundel - Journal of the American Society of …, 2011 - journals.lww.com
Abstract Calcium (Ca 2+) ions are important mediators of cellular homeostasis owing to their
ability to elicit a dynamic, transient, and tightly regulated range of biochemical responses.
More than a decade ago, a nonselective, Ca 2+-permeable, cationic conductance was
identified in podocytes downstream of angiotensin II (Ang II) signaling, but its molecular
structure remained elusive. Six years ago, transient receptor potential canonical 6 (TRPC6)
mutations were found in families with hereditary FSGS, and TRPC5 and TRPC6 channels …
ability to elicit a dynamic, transient, and tightly regulated range of biochemical responses.
More than a decade ago, a nonselective, Ca 2+-permeable, cationic conductance was
identified in podocytes downstream of angiotensin II (Ang II) signaling, but its molecular
structure remained elusive. Six years ago, transient receptor potential canonical 6 (TRPC6)
mutations were found in families with hereditary FSGS, and TRPC5 and TRPC6 channels …