[PDF][PDF] The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment

N Li, SI Grivennikov, M Karin - Cancer cell, 2011 - cell.com
Cancer cell, 2011cell.com
Tumor-associated inflammation is a consequence and a driver of tumorigenesis. Three
papers in this issue of Cancer Cell demonstrate the importance of tumor-elicited
inflammation in the development and progression of pancreatic ductal adenocarcinoma and
esophageal squamous carcinoma. Disruption of tissue homeostasis culminates in activation
of STAT3, generating a pro-tumorigenic inflammatory microenvironment.
Tumor-associated inflammation is a consequence and a driver of tumorigenesis. Three papers in this issue of Cancer Cell demonstrate the importance of tumor-elicited inflammation in the development and progression of pancreatic ductal adenocarcinoma and esophageal squamous carcinoma. Disruption of tissue homeostasis culminates in activation of STAT3, generating a pro-tumorigenic inflammatory microenvironment.
cell.com