[HTML][HTML] A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
Y Pan, B Wang - Journal of biological chemistry, 2007 - ASBMB
The proteasome usually completely degrades its target proteins, but it can also degrade a
handful of proteins in a limited and site-specific manner. The molecular mechanism for such
limited degradation is unknown. The repressor forms of Gli2 and Gli3 transcription factors
are generated from their full-length proteins through limited proteasome-mediated protein
degradation. In this study, we have taken advantage of the fact that Gli3 is efficiently
processed, whereas Gli2 is not, and identified a region of∼ 200 residues in their C termini …
handful of proteins in a limited and site-specific manner. The molecular mechanism for such
limited degradation is unknown. The repressor forms of Gli2 and Gli3 transcription factors
are generated from their full-length proteins through limited proteasome-mediated protein
degradation. In this study, we have taken advantage of the fact that Gli3 is efficiently
processed, whereas Gli2 is not, and identified a region of∼ 200 residues in their C termini …