[HTML][HTML] A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinity
G Siegenthaler, K Roulin, D Chatellard-Gruaz… - Journal of biological …, 1997 - ASBMB
We show that unsaturated fatty acids (FAs) bind reversibly and with high affinity to a
heterocomplex of 34 kDa (FA-p34) formed by the non-covalent association of two calcium-
binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9). Fatty acid-
competition studies on the [3 H] oleic acid· FA-p34-complex show that oleic, α-linoleic, γ-
linolenic, and arachidonic acids have IC 50 values of about 1 μM, whereas palmitic and
stearic acids are poor competitors. The binding of arachidonic acid is saturable with a single …
heterocomplex of 34 kDa (FA-p34) formed by the non-covalent association of two calcium-
binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9). Fatty acid-
competition studies on the [3 H] oleic acid· FA-p34-complex show that oleic, α-linoleic, γ-
linolenic, and arachidonic acids have IC 50 values of about 1 μM, whereas palmitic and
stearic acids are poor competitors. The binding of arachidonic acid is saturable with a single …