[HTML][HTML] Role of STAT3 in type I interferon responses: negative regulation of STAT1-dependent inflammatory gene activation
HH Ho, LB Ivashkiv - Journal of Biological Chemistry, 2006 - ASBMB
Type I interferons (IFNα/β) induce antiviral responses and have immunomodulatory effects
that can either promote or suppress immunity and inflammation. In myeloid cells IFNα/β
activates signal transducers and activators of transcription STAT1, STAT2, and STAT3.
STAT1 and STAT2 mediate the antiviral and inflammatory effects of IFNα/β, but the function
of IFNα/β-activated STAT3 is not known. We investigated the role of STAT3 in type I IFN
signaling in myeloid cells by modulating STAT3 expression and the intensity of STAT3 …
that can either promote or suppress immunity and inflammation. In myeloid cells IFNα/β
activates signal transducers and activators of transcription STAT1, STAT2, and STAT3.
STAT1 and STAT2 mediate the antiviral and inflammatory effects of IFNα/β, but the function
of IFNα/β-activated STAT3 is not known. We investigated the role of STAT3 in type I IFN
signaling in myeloid cells by modulating STAT3 expression and the intensity of STAT3 …