Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells
M Montes, X Zhang, L Berthelot, DA Laplaud… - Clinical …, 2009 - Elsevier
In this study, acute and chronic brain and spinal cord lesions, and normal appearing white
matter (NAWM), were resected post-mortem from a patient with aggressive relapsing-
remitting multiple sclerosis (MS). T-cell infiltrates from the central nervous system (CNS)
lesions and NAWM were separated and characterized in-vitro. All infiltrates showed a
proliferative response against multiple myelin peptides. Studies of the T-cell receptor (TCR)
Vβ and Jβ usage revealed a very skewed repertoire with shared complementarity …
matter (NAWM), were resected post-mortem from a patient with aggressive relapsing-
remitting multiple sclerosis (MS). T-cell infiltrates from the central nervous system (CNS)
lesions and NAWM were separated and characterized in-vitro. All infiltrates showed a
proliferative response against multiple myelin peptides. Studies of the T-cell receptor (TCR)
Vβ and Jβ usage revealed a very skewed repertoire with shared complementarity …