Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys
JC Crispín, M Oukka, G Bayliss, RA Cohen… - The journal of …, 2008 - journals.aai.org
JC Crispín, M Oukka, G Bayliss, RA Cohen, CA Van Beek, IE Stillman, VC Kyttaris, YT Juang…
The journal of immunology, 2008•journals.aai.orgDouble negative (DN) T cells are expanded in patients with systemic lupus erythematosus
(SLE) and stimulate autoantibody production as efficiently as CD4+ T cells. In this study, we
demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and
IFN-γ, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of
accessory cells. Furthermore, IL-17+ and DN T cells are found in kidney biopsies of patients
with lupus nephritis. Our findings establish that DN T cells produce the inflammatory …
(SLE) and stimulate autoantibody production as efficiently as CD4+ T cells. In this study, we
demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and
IFN-γ, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of
accessory cells. Furthermore, IL-17+ and DN T cells are found in kidney biopsies of patients
with lupus nephritis. Our findings establish that DN T cells produce the inflammatory …
Abstract
Double negative (DN) T cells are expanded in patients with systemic lupus erythematosus (SLE) and stimulate autoantibody production as efficiently as CD4+ T cells. In this study, we demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and IFN-γ, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of accessory cells. Furthermore, IL-17+ and DN T cells are found in kidney biopsies of patients with lupus nephritis. Our findings establish that DN T cells produce the inflammatory cytokines IL-17 and IFN-γ, and suggest that they contribute to the pathogenesis of kidney damage in patients with SLE.
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