Cure of innate intestinal immune pathology by CD4+ CD25+ regulatory T cells
KJ Maloy, LRV Antonelli, M Lefevre, F Powrie - Immunology letters, 2005 - Elsevier
CD4+ CD25+ regulatory T (TR) cells are a naturally occurring population of T cells that
suppress the development of a variety of pathological immune responses. However, as
human inflammatory diseases are usually not diagnosed until after the onset of clinical
symptoms, it is of great interest to determine whether CD4+ CD25+ TR cells can reverse
established pathology. To examine this question we have utilized a murine model of human
inflammatory bowel disease (IBD), where pathology is triggered by infection of immune …
suppress the development of a variety of pathological immune responses. However, as
human inflammatory diseases are usually not diagnosed until after the onset of clinical
symptoms, it is of great interest to determine whether CD4+ CD25+ TR cells can reverse
established pathology. To examine this question we have utilized a murine model of human
inflammatory bowel disease (IBD), where pathology is triggered by infection of immune …