Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses

G Rotiroti, M Shamji, SR Durham, SJ Till - Journal of allergy and clinical …, 2012 - Elsevier
BACKGROUND: Subcutaneous immunotherapy with high-dose grass pollen was first
described more than 100 years ago. This treatment suppresses allergen-induced cutaneous
late responses, with lesser effects on early responses. In contrast, low-dose subcutaneous
immunotherapy has not shown clinical benefit. Uncontrolled reports from the early 20th
century describe low-dose allergen inoculation directly into the dermis, an immunologically
active area containing abundant dendritic cells and lymphatics. OBJECTIVE: We sought to …