Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: Inhibition of IgE-facilitated allergen binding

S Klunker, LR Saggar, V Seyfert-Margolis… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: The combination of anti-IgE (omalizumab) therapy with ragweed injection
immunotherapy for seasonal allergic rhinitis results in a significant reduction in systemic side
effects and enhanced efficacy compared with immunotherapy alone. One proposed
mechanism of immunotherapy is to induce regulatory antibodies that inhibit facilitated
antigen presentation. OBJECTIVES: We sought to determine whether the combination
protocol has a cumulative effect on inhibition of facilitated antigen presentation both during …