Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype

A Bertolino, V Rubino, F Sambataro, G Blasi… - Biological …, 2006 - Elsevier
BACKGROUND: Studies in humans and in animals have demonstrated that a network of
brain regions is involved in performance of declarative and recognition memory tasks. This
network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal
cortex (VLPFC). Studies in animals have suggested that the relationship between these
brain regions is strongly modulated by dopamine. METHODS: Using fMRI in healthy humans
matched for a series of demographic and genetic variables, we studied the effect of the …