Choosing the right path: does DNA-PK help make the decision?
JA Neal, K Meek - … Research/Fundamental and Molecular Mechanisms of …, 2011 - Elsevier
DNA double-strand breaks are extremely harmful lesions that can lead to genomic instability
and cell death if not properly repaired. There are at least three pathways that are
responsible for repairing DNA double-strand breaks in mammalian cells: non-homologous
end joining, homologous recombination and alternative non-homologous end joining. Here
we review each of these three pathways with an emphasis on the role of the DNA-
dependent protein kinase, a critical component of the non-homologous end joining pathway …
and cell death if not properly repaired. There are at least three pathways that are
responsible for repairing DNA double-strand breaks in mammalian cells: non-homologous
end joining, homologous recombination and alternative non-homologous end joining. Here
we review each of these three pathways with an emphasis on the role of the DNA-
dependent protein kinase, a critical component of the non-homologous end joining pathway …