[HTML][HTML] Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition
H Xiong, J Hong, W Du, Y Lin, L Ren, Y Wang… - Journal of Biological …, 2012 - ASBMB
The progression of colorectal carcinoma (CRC) to invasive and metastatic disease may
involve localized occurrences of epithelial-mesenchymal transition (EMT). However,
mechanisms of the EMT process in CRC progression are not fully understood. We
previously showed that knockdown of signal transducer and activator of transcription 3
(STAT3) up-regulated E-cadherin (a key component in EMT progression) in CRC. In this
study, we examined the roles of STAT3 in CRC EMT and ZEB1, an EMT inducer, in STAT3 …
involve localized occurrences of epithelial-mesenchymal transition (EMT). However,
mechanisms of the EMT process in CRC progression are not fully understood. We
previously showed that knockdown of signal transducer and activator of transcription 3
(STAT3) up-regulated E-cadherin (a key component in EMT progression) in CRC. In this
study, we examined the roles of STAT3 in CRC EMT and ZEB1, an EMT inducer, in STAT3 …