[HTML][HTML] Divalent cations and ligands induce conformational changes that are highly divergent among β1 integrins

G Bazzoni, L Ma, ML Blue, ME Hemler - Journal of Biological Chemistry, 1998 - ASBMB
Here we show striking differences in conformational regulation among β 1 integrins. Upon
manganese stimulation, a β 1 epitope defined by monoclonal antibody (mAb) 9EG7 was
induced strongly (on α 4 β 1), moderately (on α 5 β 1), weakly (on α 2 β 1), or was scarcely
detectable (on α 6 β 1 and α 3 β 1). Comparable results were seen for the β 1 epitope
defined by mAb 15/7. Likewise, soluble ligands caused strong (α 4 β 1), moderate (α 5 β 1),
weak (α 2 β 1, α 6 β 1), or minimal (α 3 β 1) induction of the 9EG7 epitope. Exchange or …