Gliomas are the most frequent primary tumors of the central nervous system in adults. The
most prevalent and aggressive subclass of these is glioblastoma multiforme, which is
characterized by massive neovascularization. Endosialin (CD248) has generated interest as
a target for antiangiogenic therapy following reports that its expression is upregulated on
angiogenic endothelial cells. We demonstrate here that endosialin is not expressed in
normal human adult brain but is strongly upregulated in the angiogenic vasculature of all …