Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development
J MacFadyen, K Savage, D Wienke, CM Isacke - Gene Expression Patterns, 2007 - Elsevier
Endosialin has been assigned the alternate name of tumour endothelial marker 1 (TEM1)
due to its identification as a highly upregulated gene transcript in tumour endothelium
compared to normal endothelium. As a consequence there is interest in endosialin as a
potential therapeutic target in cancer treatment. However, there are conflicting reports over
the nature of vascular expression in tumours with some evidence that endosialin is
expressed on perivascular pericytes rather than the endothelial cells themselves. To …
due to its identification as a highly upregulated gene transcript in tumour endothelium
compared to normal endothelium. As a consequence there is interest in endosialin as a
potential therapeutic target in cancer treatment. However, there are conflicting reports over
the nature of vascular expression in tumours with some evidence that endosialin is
expressed on perivascular pericytes rather than the endothelial cells themselves. To …