Transport of molecules across tumor vasculature

RK Jain - Cancer and Metastasis Reviews, 1987 - Springer
Cancer and Metastasis Reviews, 1987Springer
The vascular-extravascular exchange of fluid and solute molecules in a tissue is determined
by three transport parameters (vascular permeability, P, hydraulic conductivity, L p, and
reflection coefficient, σ); the surface area for exchange, A; and the transluminal
concentration and pressure gradients. The transport parameters and the exchange area for
a given molecule are governed by the structure of the vessel wall. In general, tumor vessels
have wide interendothelial junctions; large number of fenestrae and transendothelial …
Abstract
The vascular-extravascular exchange of fluid and solute molecules in a tissue is determined by three transport parameters (vascular permeability, P, hydraulic conductivity, Lp, and reflection coefficient, σ); the surface area for exchange, A; and the transluminal concentration and pressure gradients. The transport parameters and the exchange area for a given molecule are governed by the structure of the vessel wall. In general, tumor vessels have wide interendothelial junctions; large number of fenestrae and transendothelial channels formed by vesicles; and discontinuous or absent basement membrane. While these factors favor movement of molecules across tumor vessels, high interstitial pressure and low microvascular pressure may retard extravasation of molecules and cells, especially in large tumors. These characteristics of the transvascular transport have significant implications in tumor growth, metastasis, detection and treatment.
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