Leishmaniaspp.: Mechanisms of toxicity of nitrogen oxidation products
J Mauël, A Ransijn - Experimental parasitology, 1997 - Elsevier
Intracellular killing ofLeishmaniaparasites within activated murine macrophages is thought
to result from the toxic activities of nitrogen oxidation products (referred to as NO) released
by the activated cells. In order to determine possible mechanisms of NO toxicity for these
microorganisms, promastigotes ofLeishmania majorandLeishmania enriettiiwere exposed to
NO generated chemically from acidified nitrite, S-nitrosocysteine, diethylamine NONOate, or
nitroprusside. Treatment with these agents led to loss of viability (as determined from …
to result from the toxic activities of nitrogen oxidation products (referred to as NO) released
by the activated cells. In order to determine possible mechanisms of NO toxicity for these
microorganisms, promastigotes ofLeishmania majorandLeishmania enriettiiwere exposed to
NO generated chemically from acidified nitrite, S-nitrosocysteine, diethylamine NONOate, or
nitroprusside. Treatment with these agents led to loss of viability (as determined from …