[HTML][HTML] Specific armadillo repeat sequences facilitate β-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62, Nup153, and RanBP2/Nup358

M Sharma, C Jamieson, M Johnson, MP Molloy… - Journal of Biological …, 2012 - ASBMB
β-Catenin transduces the Wnt signal from the membrane to nucleus, and certain gene
mutations trigger its nuclear accumulation leading to cell transformation and cancer. β-
Catenin shuttles between the nucleus and cytoplasm independent of classical Ran/transport
receptor pathways, and this movement was previously hypothesized to involve the central
Armadillo (Arm) domain. Fluorescence recovery after photobleaching (FRAP) assays were
used to delineate functional transport regions of the Arm domain in living cells. The strongest …