Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone …
RA Nissenson, D Diep, GJ Strewler - Journal of Biological Chemistry, 1988 - ASBMB
A tumor-derived protein with a spectrum of biologic activities remarkably similar to that of
parathyroid hormone (PTH) has recently been purified and its sequence deduced from
cloned cDNA. This PTH-like protein (PLP) has substantial sequence homology with PTH
only in the amino-terminal 1-13 region and shows little similarity to other regions of PTH
thought to be important for binding to receptors. In the present study, we compared the
actions of two synthetic PLP peptides, PLP-(1-34) amide and [Tyr36] PLP-(1-36) amide, with …
parathyroid hormone (PTH) has recently been purified and its sequence deduced from
cloned cDNA. This PTH-like protein (PLP) has substantial sequence homology with PTH
only in the amino-terminal 1-13 region and shows little similarity to other regions of PTH
thought to be important for binding to receptors. In the present study, we compared the
actions of two synthetic PLP peptides, PLP-(1-34) amide and [Tyr36] PLP-(1-36) amide, with …