The Ku heterodimer plays an essential role in non-homologous end-joining and other
cellular processes including transcription, telomere maintenance and apoptosis. While the
function of Ku is regulated through its association with other proteins and nucleic acids, the
specific composition of these macromolecular complexes and their dynamic response to
endogenous and exogenous cellular stimuli are not well understood. Here we use
quantitative proteomics to define the composition of Ku multicomponent complexes and …