SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma
Y Gen, K Yasui, Y Zen, K Zen, O Dohi, M Endo… - Cancer genetics and …, 2010 - Elsevier
SOX2 is a transcription factor with a high-mobility group DNA-binding domain that functions
as a master regulator during embryogenesis and organogenesis. We investigated DNA copy
number aberrations in esophageal squamous cell carcinoma (ESCC) cell lines using a high-
density oligonucleotide microarray and found frequent amplification at the chromosomal
region 3q26. The estimated extent of the minimal overlapping region of amplification was 1.3
Mb. This chromosomal region includes a single gene, SOX2. The SOX2 protein was …
as a master regulator during embryogenesis and organogenesis. We investigated DNA copy
number aberrations in esophageal squamous cell carcinoma (ESCC) cell lines using a high-
density oligonucleotide microarray and found frequent amplification at the chromosomal
region 3q26. The estimated extent of the minimal overlapping region of amplification was 1.3
Mb. This chromosomal region includes a single gene, SOX2. The SOX2 protein was …