[HTML][HTML] Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation
Q Shi, S Bao, JA Maxwell, ED Reese… - Journal of Biological …, 2004 - ASBMB
Secreted protein acidic, rich in cysteine (SPARC), is an extracellular matrix protein
expressed in many advanced cancers, including malignant gliomas. We and others have
previously shown that human glioma cell lines engineered to overexpress SPARC adopt an
invasive phenotype. We now show that SPARC expression increases cell survival under
stress initiated by serum withdrawal through a decrease in apoptosis. Phosphatidylinositol 3-
OH kinase/AKT is a potent pro-survival pathway that contributes to the malignancy of …
expressed in many advanced cancers, including malignant gliomas. We and others have
previously shown that human glioma cell lines engineered to overexpress SPARC adopt an
invasive phenotype. We now show that SPARC expression increases cell survival under
stress initiated by serum withdrawal through a decrease in apoptosis. Phosphatidylinositol 3-
OH kinase/AKT is a potent pro-survival pathway that contributes to the malignancy of …