[HTML][HTML] The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin β1 and activation of integrin-linked kinase
MS Weaver, G Workman, EH Sage - Journal of Biological Chemistry, 2008 - ASBMB
Secreted protein acidic and rich in cysteine (SPARC) is important for the normal growth and
maintenance of the murine lens. SPARC-null animals develop cataracts associated with a
derangement of the lens capsule basement membrane and alterations in lens fiber
morphology. Cellular stress and disregulation of apoptotic pathways within lens epithelial
cells (LEC) are linked to cataract formation. To identify molecular targets of SPARC that are
linked to this disorder, we stressed wild-type (WT) and SPARC-null LEC by serum …
maintenance of the murine lens. SPARC-null animals develop cataracts associated with a
derangement of the lens capsule basement membrane and alterations in lens fiber
morphology. Cellular stress and disregulation of apoptotic pathways within lens epithelial
cells (LEC) are linked to cataract formation. To identify molecular targets of SPARC that are
linked to this disorder, we stressed wild-type (WT) and SPARC-null LEC by serum …