The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
JJ Zhao, H Cheng, S Jia, L Wang… - Proceedings of the …, 2006 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2006•National Acad Sciences
Growth factor signaling is mediated through Class IA phosphatidylinositol 3-kinases (PI3Ks).
Among this class of enzymes, only p110α, encoded by the PIK3CA gene, has been found to
be mutant in human cancers. To determine the specific functions of p110α, we generated
mice carrying a conditionally targeted allele of the PIK3CA gene. Here, we report that
PIK3CA-knockout mouse embryonic fibroblasts are deficient in cellular signaling in
response to various growth factors, unable to differentiate into adipocytes, and resistant to …
Among this class of enzymes, only p110α, encoded by the PIK3CA gene, has been found to
be mutant in human cancers. To determine the specific functions of p110α, we generated
mice carrying a conditionally targeted allele of the PIK3CA gene. Here, we report that
PIK3CA-knockout mouse embryonic fibroblasts are deficient in cellular signaling in
response to various growth factors, unable to differentiate into adipocytes, and resistant to …
Growth factor signaling is mediated through Class IA phosphatidylinositol 3-kinases (PI3Ks). Among this class of enzymes, only p110α, encoded by the PIK3CA gene, has been found to be mutant in human cancers. To determine the specific functions of p110α, we generated mice carrying a conditionally targeted allele of the PIK3CA gene. Here, we report that PIK3CA-knockout mouse embryonic fibroblasts are deficient in cellular signaling in response to various growth factors, unable to differentiate into adipocytes, and resistant to oncogenic transformation induced by a variety of oncogenic receptor tyrosine kinases, indicating a fundamental role for p110α in these biological processes.
National Acad Sciences