Control of the alloimmune response requires elimination and/or suppression of alloreactive
immune cells. Lymphodepleting induction therapies are increasingly used to accomplish this
goal, both as part of tolerance induction protocols or to reduce the requirements for
maintenance immunosuppression in the peritransplant setting. However, it is well
recognized that lymphopenia induces compensatory proliferation of immune cells, generally
termed “homeostatic proliferation,” which favors the emergence of memory T cells …