[HTML][HTML] Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade
Y Wang, H Dai, Z Liu, X Cheng, G Tellides… - American journal of …, 2006 - Elsevier
Memory T cells are somewhat resistant to immunosuppresion. They therefore pose a threat
to inducing long-term allograft survival. IL-7 is essential for memory T-cell generation. Here,
we investigated whether neutralizing IL-7 promotes allograft survival. We found that
neutralizing IL-7 alone did not significantly prolong allograft survival. However, blocking both
IL-7 and CD154 signaling synergistically prolonged allograft survival. In contrast,
neutralizing IL-2 failed to further prolong allograft survival induced by CD40/CD154 …
to inducing long-term allograft survival. IL-7 is essential for memory T-cell generation. Here,
we investigated whether neutralizing IL-7 promotes allograft survival. We found that
neutralizing IL-7 alone did not significantly prolong allograft survival. However, blocking both
IL-7 and CD154 signaling synergistically prolonged allograft survival. In contrast,
neutralizing IL-2 failed to further prolong allograft survival induced by CD40/CD154 …