Synchronous multiple ipsilateral breast cancers: implications for patient management

S Jain, A Rezo, B Shadbolt, JE Dahlstrom - Pathology, 2009 - Elsevier
Interest in the presence and management of synchronous multiple ipsilateral breast cancer
has been reported since the early 1920s. The demonstration of multiple foci of breast cancer
has been reported in 9–75% of breast cancer related specimens. The large difference in
reported incidence is multifactorial and related to the definitions applied, mode of detection
and pathological assessment. However, randomised clinical trials comparing total
mastectomy and segmental mastectomy with or without radiation over many years have …