Characterization of two major populations of lung fibroblasts: distinguishing morphology and discordant display of Thy 1 and class II MHC
RP Phipps, DP Penney, P Keng, H Quill… - Am J Respir Cell Mol …, 1989 - atsjournals.org
RP Phipps, DP Penney, P Keng, H Quill, A Paxhia, S Derdak, ME Felch
Am J Respir Cell Mol Biol, 1989•atsjournals.orgThe lung is a highly complex organ consisting of many types of celIs including fibroblasts,
lymphocytes, macrophages, Clara celIs, endothelial celIs, and pneumocytes. An
inflammatory response in the lung, as a result of chemotherapy or injury from radiation, may
be associated with progressive thickening of the alveolar interstitium and deposition of a
dense fibrotic matrix composed primarily of collagen (1, 2). Once initiated, radiation-induced
pulmonary fibrosis is irreversible (3, 4).
lymphocytes, macrophages, Clara celIs, endothelial celIs, and pneumocytes. An
inflammatory response in the lung, as a result of chemotherapy or injury from radiation, may
be associated with progressive thickening of the alveolar interstitium and deposition of a
dense fibrotic matrix composed primarily of collagen (1, 2). Once initiated, radiation-induced
pulmonary fibrosis is irreversible (3, 4).
The lung is a highly complex organ consisting of many types of celIs including fibroblasts, lymphocytes, macrophages, Clara celIs, endothelial celIs, and pneumocytes. An inflammatory response in the lung, as a result of chemotherapy or injury from radiation, may be associated with progressive thickening of the alveolar interstitium and deposition of a dense fibrotic matrix composed primarily of collagen (1, 2). Once initiated, radiation-induced pulmonary fibrosis is irreversible (3, 4).
ATS Journals