TGF-β: the missing link in CD4+ CD25+ regulatory T cell-mediated immunosuppression
WJ Chen, SM Wahl - Cytokine & growth factor reviews, 2003 - Elsevier
A unique population of CD4+ T lymphocytes that constitutively express CD25 has been
recognized as anergic/suppressor cells. While the immunosuppressive activity of these
CD4+ CD25+ cells has been validated and implicated in tolerance, autoimmunity,
transplantation, cancer and infectious diseases, the mechanism (s) by which they function
still remains controversial. Although the involvement of TGF-β was initially discounted,
emerging evidence now links this cytokine with CD4+ CD25+ T cell-mediated suppression …
recognized as anergic/suppressor cells. While the immunosuppressive activity of these
CD4+ CD25+ cells has been validated and implicated in tolerance, autoimmunity,
transplantation, cancer and infectious diseases, the mechanism (s) by which they function
still remains controversial. Although the involvement of TGF-β was initially discounted,
emerging evidence now links this cytokine with CD4+ CD25+ T cell-mediated suppression …