CD8+ suppressor T cells resurrected

JA Kapp, RP Bucy - Human immunology, 2008 - Elsevier
This review focuses on the role of antigen-specific T cells that mediate active inhibition of
immune responses over the past 35 years since their initial description. The field has
experienced several changes in the accepted paradigm of such suppressor/regulatory T
cells, from initial indications that such cells were CD8+, to the view that such cells did not
exist, to the identification of the transcription factor Foxp3 as a key orchestrator of inhibitory
function. Although most Foxp3+ cells in a resting animal are CD4+ CD25+ cells, Foxp3 …