PI-loting membrane traffic
MAD Matteis, A Godi - Nature cell biology, 2004 - nature.com
MAD Matteis, A Godi
Nature cell biology, 2004•nature.comPhosphoinositides (PIs) undergo phosphorylation/dephosphorylation cycles through
organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular
distributions of the individual PI species. Specific PIs control the correct timing and location
of many trafficking events. Their ultimate mode of action is not always well defined, but it
includes localized recruitment of transport machinery, allosteric regulation of PI-binding
proteins and changes in the physical properties of the membrane.
organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular
distributions of the individual PI species. Specific PIs control the correct timing and location
of many trafficking events. Their ultimate mode of action is not always well defined, but it
includes localized recruitment of transport machinery, allosteric regulation of PI-binding
proteins and changes in the physical properties of the membrane.
Abstract
Phosphoinositides (PIs) undergo phosphorylation/dephosphorylation cycles through organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular distributions of the individual PI species. Specific PIs control the correct timing and location of many trafficking events. Their ultimate mode of action is not always well defined, but it includes localized recruitment of transport machinery, allosteric regulation of PI-binding proteins and changes in the physical properties of the membrane.
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