Studying the mononuclear phagocyte system in the molecular age
The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and
dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability
and myeloid classification; however, the factors that regulate the differentiation, homeostasis
and function of macrophages and dendritic cells remain largely unknown. The purpose of
this manuscript is to review the tools that are currently available and those that are under
development to study the origin and function of mononuclear phagocytes.
dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability
and myeloid classification; however, the factors that regulate the differentiation, homeostasis
and function of macrophages and dendritic cells remain largely unknown. The purpose of
this manuscript is to review the tools that are currently available and those that are under
development to study the origin and function of mononuclear phagocytes.
Abstract
The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability and myeloid classification; however, the factors that regulate the differentiation, homeostasis and function of macrophages and dendritic cells remain largely unknown. The purpose of this manuscript is to review the tools that are currently available and those that are under development to study the origin and function of mononuclear phagocytes.
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