The adult mammalian heart has an extremely limited capacity for regeneration. As a
consequence, ischemic heart disease remains the leading cause of death in the developed
world, and the heart continues to be a major focal point for regenerative medicine.
Understanding innate mechanisms of heart regeneration is important and may provide a
blueprint for clinical translation. For example, urodele amphibians and teleost fish can mount
an endogenous regenerative response following multiple forms of cardiac injury, and this …