Activated pericytes and the inhibition of renal vascular stability: obstacles for kidney repair

DP Basile, TA Sutton - Journal of the American Society of …, 2012 - journals.lww.com
The hallmark feature of CKD and its progression to end stage is the presence and severity of
interstitial fibrosis. 1, 2 This longrecognized association is the prime driving force of research
to understand the nature of renal scarification. Much of the research in this area can be
grouped into one of two broad categories: efforts geared toward understanding the
biochemical and pathophysiological factors that govern the degree of progression and
efforts aimed at defining the cellular and molecular elements that comprise renal scars. With …